“The ruin of the world then is preceded by certain of the world's calamities, such as famine, pestilence, and persecution.”
Ambrose of Milan, 4th c. — Catena Aurea by Aquinas
Original
11And great earthquakes shall be in divers places, and famines, and pestilences; and fearful sights and great signs shall there be from heaven.
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In context
9But when ye shall hear of wars and commotions, be not terrified: for these things must first come to pass; but the end is not by and by.
10Then said he unto them, Nation shall rise against nation, and kingdom against kingdom:
— Luke 21:11 —
12But before all these, they shall lay their hands on you, and persecute you, delivering you up to the synagogues, and into prisons, being brought before kings and rulers for my name’s sake.