“"And I saw an angel flying through the midst of heaven." By the angel flying through the midst of heaven is signified the Holy Spirit beating witness in two of the prophets that a great wrath of plagues was imminent. If by any means, even in the last times, any one should be willing to be converted, any one might even…”
Victorinus of Pettau, 4th c. — Commentary on the Apocalypse of the Blessed John
Original
13And I beheld, and heard an angel flying through the midst of heaven, saying with a loud voice, Woe, woe, woe, to the inhabiters of the earth by reason of the other voices of the trumpet of the three angels, which are yet to sound!
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In context
11And the name of the star is called Wormwood: and the third part of the waters became wormwood; and many men died of the waters, because they were made bitter.
12And the fourth angel sounded, and the third part of the sun was smitten, and the third part of the moon, and the third part of the stars; so as the third part of them was darkened, and the day shone not for a third part of it, and the night likewise.