“The history of Isaac, too, is not without a symbolical character. For in the Epistle to the Romans, the apostle declares: "Moreover, when Rebecca had conceived by one, even by our father Isaac," she received answer from the Word, "that the purpose of God according to election might stand, not of works, but of Him that…”
Irenaeus, 3th c. — Irenaeus Against Heresies Book 4
Original
10And not only this; but when Rebecca also had conceived by one, even by our father Isaac;
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In context
8That is, They which are the children of the flesh, these are not the children of God: but the children of the promise are counted for the seed.
9For this is the word of promise, At this time will I come, and Sarah shall have a son.
— Romans 9:10 —
11(For the children being not yet born, neither having done any good or evil, that the purpose of God according to election might stand, not of works, but of him that calleth;)
12It was said unto her, The elder shall serve the younger.