“All of these plagues are spiritual, and they occur in the soul. For at that time the whole people of the impious will be unharmed by any plague of the body, because they were undeserving to be chastised in the present age, and it was as though they had received all the power of causing pain. However, spiritually all w…”
Caesarius of Arles, 6th c. — EXPOSITION ON THE APOCALYPSE 16:2, HOMILY 12
Original
2And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.
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In context
1And I heard a great voice out of the temple saying to the seven angels, Go your ways, and pour out the vials of the wrath of God upon the earth.
— Revelation 16:2 —
3And the second angel poured out his vial upon the sea; and it became as the blood of a dead man: and every living soul died in the sea.
4And the third angel poured out his vial upon the rivers and fountains of waters; and they became blood.